You can declare 2 vars for example
Dim FirstPanel As panel
Dim FirstRun As Boolean
Dim HelpScr As Boolean : HelpScr = False
...
...
Also you can use <<statemanager class>> to save "FirstRun"
Sub Activity_Create(FirstTime As Boolean)
...
...
' Only will show the Help Panel on the first run
If FirstRun = True Then
FirstPanel.Visible = True 'Your Help Panel(s)
HelpScr = True
Else
firstpanel.Visible = False
HelpScr = False
End If
StateManager.SetSetting("FirstRun",False)
StateManager.SaveSettings