You have not assigned any values to Number1 and Number2.
Try:
Sub Enter_Click
Number1 = Weight.Text
Number2 = Squat.text
lblComment.Text = Number1*18.33/Number2
End Sub
Also note that in the above example the words Public and Private can be removed since Activity variables are always private. The Private keyword is useful in Process_Globals since process variables are all Public.
Tip: in the designer set the edit boxes to input type = DECIMAL NUMBERS
bluejay